Phenomenology and Connectionism

I show how the dynamics of consciousness can be formally derived from the “open dynamics” of neural activity, and develop a mathematical framework for neuro-phenomenological investigation. I describe the space of possible brain states, the space of possible conscious states, and a “supervenience function” linking them. I show how this framework can be used to associate phenomenological structures with neuro-computational structures, and vice-versa. I pay special attention to the relationship between (1) the relatively fast dynamics of consciousness and neural activity, and (2) the slower dynamics of knowledge update and brain development

Joint perceptual decision-making: a case study in explanatory pluralism.

Traditionally different approaches to the study of cognition have been viewed as competing explanatory frameworks. An alternative view, explanatory pluralism, regards different approaches to the study of cognition as complementary ways of studying the same phenomenon, at specific temporal and spatial scales, using appropriate methodological tools. Explanatory pluralism has been often described abstractly, but has rarely been applied to concrete cases. We present a case study of explanatory pluralism. We discuss three separate ways of studying the same phenomenon: a perceptual decision-making task (Bahrami et al., 2010), where pairs of subjects share information to jointly individuate an oddball stimulus among a set of distractors. Each approach analyzed the same corpus but targeted different units of analysis at different levels of description: decision-making at the behavioral level, confidence sharing at the linguistic level, and acoustic energy at the physical level. We discuss the utility of explanatory pluralism for describing this complex, multiscale phenomenon, show ways in which this case study sheds new light on the concept of pluralism, and highlight good practices to critically assess and complement approaches

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines designed for nervous system-specific recombination. Selective maternal or paternal germline recombination is showcased with sample Cre lines. Collated data reveal germline recombination in over half of 64 commonly used Cre driver lines, in most cases with a parental sex bias related to Cre expression in sperm or oocytes. Slight differences among Cre driver lines utilizing common transcriptional control elements affect germline recombination rates. Specific target loci demonstrated differential recombination; thus, reporters are not reliable proxies for another locus of interest. Similar principles apply to other recombinase systems and other genetically targeted organisms. We hereby draw attention to the prevalence of germline recombination and provide guidelines to inform future research for the neuroscience and broader molecular genetics communities

Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions

Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared to mobilized peripheral blood stem cells (PBSC). We hypothesized that this recommendation may not apply to those regions where patients present later in their disease course, with heavier transfusion load and with higher graft failure rates. Patients with SAA who received HSCT from an HLA-matched sibling donor from 1995 to 2009 and reported to the Center for International Blood and Marrow Transplant Research or the Japan Society for Hematopoietic Cell Transplantation were analyzed. The study population was categorized by gross national income per capita (GNI) and region/countries into four groups. Groups analyzed were high income countries (HIC), which were further divided into US-Canada (N=486) and other HIC (N=1264), upper middle-income (UMIC) (N=482), and combined lower middle, low income countries (LM-LIC) (N=142). In multivariate analysis, overall survival (OS) was highest with BM as graft source in HIC compared to PBSC in all countries or BM in UMIC or LM-LIC (p<0.001). There was no significant difference in OS between BM and PBSC in UMIC (p=0.32) or LM-LIC (p=0.23). In LM-LIC the 28-day neutrophil engraftment was higher with PBSC compared to BM (97% vs. 77%, p<0.001). Chronic GVHD was significantly higher with PBSC in all groups. Whereas BM should definitely be the preferred graft source for HLA-matched sibling HSCT in SAA, PBSC may be an acceptable alternative in countries with limited resources when treating patients at high risk of graft failure and infective complications

Mapping the Structure of Debate

Although debate is a richly structured and prevalent form of discourse, it has received little scholarly attention. Logicians have focused on the structure of individual arguments-how they divide into premises and conclusions, which in turn divide into various constituents. In contrast, I focus on the structure of sets of arguments, showing how arguments are themselves constituents in high-level dialectical structures. I represent debates and positions by graphs whose vertices correspond to arguments and whose edges correspond to two inter-argument relations: "dispute" and "support," respectively. On this basis I develop a theory of the structure of debate

Saygin, A.P. (2001) &apos;Review of Horn, R. et.al. Mapping Great Debates: Can Computers Think? Seven maps and a handbook&apos;. Minds and Machines 11(3): 442-445

Anyone interested in artificial intelligence knows how difficult it can be to find comprehensive material on the subject. Textbooks usually cannot cover all interdisciplinary aspects, and review papers are typically specialized in a particular area within the field. This poses a problem for students, but can also be a serious difficulty for the advanced researcher. Few people would claim to have competency in all aspects of artificial intelligence research. The field knows no disciplinary boundaries and the arguments span decades. Articles can be hard to locate and scattered across publications relevant to several different disciplines. Bibliographies can easily miss older or more obscure articles that may be of interest. Comprehensive and interdisciplinary resources that can act as starting points for learning or teaching artificial intelligence are increasingly needed as the field rapidly gains importance, depth and breadth. Consider a few examples: You may have spent years working in artificial intelligence, but still need direction to find information on a question outside your area of focus. Or you may be a student who heard about Searle’s Chinese Room (1980) in class and are interested in finding out what sort of responses this argument received. Or perhaps you are writing a paper on the Turing Test, sitting among a huge pile of papers spanning 50 years, trying to figure out “who-said-what-to-whom”... Where do you go? Would you ask your colleagues or your professors? Would you go to the library or search the web? Wouldn’t it be good if you had a resource to giv

Hematopoietic stem cell transplantation: a global perspective

Hematopoietic stem cell transplantation (HSCT) requires significant infrastructure. Little is known about HSCT use and the factors associated with it on a global level

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines:Prevalence of Germline Recombination and Influencing Factors

Luo et al. report variable rates of germline recombination in commonly used mouse Cre driver lines, influenced by sex of Cre-carrying parents and target loci. Guidelines are provided to optimize cell-type-specific recombination in genetically targeted organisms expressing site-specific recombinases